Medicine

Progressing ASO therapies from progression to implementation

.Completing interests.R.S., M.S., H.G. as well as A.A.R. are actually organizers of the 1M1M project. H.G. and also A.A.R. are actually panel of supervisors participants and also R.S., M.S. and also A.A.R. are participants of the clinical consultatory board of N1C. A.A.R. makes known employment through LUMC, which possesses patents on exon-skipping technology, a number of which has been licensed to BioMarin as well as subsequently sublicensed to Sarepta. As co-inventor of a few of these licenses, A.A.R. was allowed to a portion of royalties. A.A.R. better discloses functioning as expert for PTC Therapies, Sarepta Therapies, Regenxbio, Dyne Therapeutics, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco as well as Astra Zeneca. In the past 5 years, A.A.R. also carried out getting in touch with for Alpha Anomeric. A.A.R. likewise states registration of the clinical boards of advisers of Eisai, Hybridize Rehabs, Silence Therapeutics, Sarepta Rehabs, Sapreme and Mitorx. In the past 5 years, A.A.R. was actually also a scientific advisory board participant for ProQR. Remuneration for A.A.R. u00e2 s consulting and also advising activities is actually paid to LUMC. Over the last 5 years, LUMC also got sound speaker gratuity from PTC Therapeutics, Alnylam Netherlands, Italfarmaco as well as Pfizer and also cashing for contract analysis from Sapreme, Eisai, Galapagos, Synaffix and also Alpha Anomeric. Task financing is actually received coming from Sarepta Rehabs as well as Entrada using unrestricted gives. H.G. has absolutely nothing to divulge in regard to the subject matters covered in this particular manuscript. Before 5 years, he has also obtained working as a consultant gratuity from UCB. M.S. received working as a consultant gratuity coming from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and Solaxa in the past 5 years, all unrelated to the present manuscript. R.S. possesses absolutely nothing to divulge relative to the topics dealt with within this document. She has actually received speaker and/or working as a consultant honoraria or funding payments coming from Abbvie, Bial, STADA as well as Everpharma over the last 5 years.